{"id":555,"date":"2020-06-16T10:39:11","date_gmt":"2020-06-16T10:39:11","guid":{"rendered":"http:\/\/icdlabs.in\/immune-internal\/?page_id=555"},"modified":"2024-06-18T11:00:21","modified_gmt":"2024-06-18T11:00:21","slug":"science","status":"publish","type":"page","link":"https:\/\/icdlabs.in\/immune-internal\/science\/","title":{"rendered":"Science"},"content":{"rendered":"<div class=\"lazyblock-global-page-heading-jlfC9 wp-block-lazyblock-global-page-heading\"><!-- Include stylesheet -->\n\n    <section class=\"global-section1\">\n        <div class=\"container\">\n            <h1 class=\"page-heading\">science<\/h1>\n        <\/div>\n    <\/section>\n<\/div>\n\n<div class=\"lazyblock-science-section-1-YJCw wp-block-lazyblock-science-section-1\"><!-- Include stylesheet -->\n\n<section class=\"science-section1 section-body-content\">\n    <!-- <div class=\"dna-anim\" id=\"dnaanim\"><\/div> -->\n    <div class=\"container position-relative\">\n        <div class=\"dna-anim-video d-lg-block d-none hide-on-ie\">\n            <video src=\"https:\/\/icdlabs.in\/immune-internal\/wp-content\/themes\/immuneel\/assets\/videos\/DNA.mp4\" preload=\"metadata\" autoplay loop muted><\/video>\n        <\/div>\n        <div class=\"anim-img d-lg-none d-block show-on-ie\">\n            <img decoding=\"async\" src=\"https:\/\/icdlabs.in\/immune-internal\/wp-content\/themes\/immuneel\/assets\/images\/science\/dna-comp.png\" alt=\"\">\n        <\/div>\n        <div class=\"row\">\n            <div class=\"col-lg-5 offset-lg-4 science-section1-content\">\n                <h3><strong>Cure on the horizon:<\/strong> Cell and gene therapy<\/h3>\n                <div class=\"line-anim\"><\/div>\n            <\/div>\n        <\/div>\n        <div class=\"row\">\n            <div class=\"col-lg-8 offset-lg-4\">\n                <div class=\"col-count\">\n                    <p>For the first time, the promise of lasting remission for a few cancers such as leukemias and lymphomas, as well as genetic disorders is on the horizon. Cell and gene therapies could provide lasting cure by either rectifying genetic deficiencies that cause disease or, through genetic engineering, modify healthy immune cells to target cancerous cells smartly. Cell and gene therapies could thus restore the body to its disease-free state in the case of simple genetic diseases or enhance the immune system to target abnormal cells as with cancer.<\/p>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n\n<div class=\"lazyblock-science-section-2-aslfd wp-block-lazyblock-science-section-2\"><!-- Include stylesheet -->\n\n<div id=\"cellular-immunotherapies\" class=\"section-id\"><\/div>\n<section class=\"science-section2\" id=\"cellular-immunotherapies\">\n    <!-- <div class=\"science-anim2-video\"><video src=\"https:\/\/icdlabs.in\/immune-internal\/wp-content\/themes\/immuneel\/assets\/videos\/science\/science-anim-3.mp4\" autoplay loop muted><\/video><\/div> -->\n    <div class=\"container position-relative\">\n        <div class=\"row section-body-content\">\n            <div class=\"col-lg-4\">\n                <h3><strong>Cellular immunotherapies:<\/strong> Living drugs<\/h3>\n            <\/div>\n            <!-- <div class=\"col-lg-4\">\n                <p>The immune system is the body\u2019s natural defense against infections and old or abnormal cells including those that make up cancer. Cellular immunotherapy strategies utilize immune cells from the patient (or donor) that are then genetically altered, outside the body <em>(ex-vivo), <\/em>and re-infused into the patient. Since live cells are re-engineered to fight the disease, cellular immunotherapies are considered \u2018living drugs\u2019. These therapies have the potential to address complex conditions previously considered untreatable.<\/p>            <\/div>\n            <div class=\"col-lg-4\">\n                            <\/div> -->\n            <div class=\"col-lg-8\">\n                <div class=\"col-count\">\n                    <p>The immune system is the body\u2019s natural defense against infections and old or abnormal cells including those that make up cancer. Cellular immunotherapy strategies utilize immune cells from the patient (or donor) that are then genetically altered, outside the body <em>(ex-vivo), <\/em>and re-infused into the patient. Since live cells are re-engineered to fight the disease, cellular immunotherapies are considered \u2018living drugs\u2019. These therapies have the potential to address complex conditions previously considered untreatable.<\/p>                <\/div>\n            <\/div>\n        <\/div>\n        <div class=\"row\">\n            <div class=\"col-lg-8 science-anim-pad\">\n                <div class=\"science-anim2 svg-anim-cont\" id=\"scienceAnim2\"><\/div>\n            <\/div>\n            <div class=\"col-lg-4\">\n                <div class=\"cell-therapy\">\n                    <!-- <div class=\"line-anim\"><\/div> -->\n                    <p>Lymphocytes, a type of white blood cells, is emerging as the cornerstone of cell-based immunotherapies.<\/p>\n<p>Currently cell-based immunotherapies that are currently being evaluated in the fight against cancer seek to utilize:<\/p>\n<ul>\n<li>Tumor-Infiltrating Lymphocytes<\/li>\n<li>Engineered T Cells with modified T Cell Receptors (TCR) or Chimeric Antigen Receptor<\/li>\n<li>Natural Killer (NK) Cells<\/li>\n<li>Monocytes<\/li>\n<\/ul>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n\n<div class=\"lazyblock-science-section-3-Z1vAd5u wp-block-lazyblock-science-section-3\"><!-- Include stylesheet -->\n\n<div id=\"how-living-drugs-are-made\" class=\"section-id\"><\/div>\n<section class=\"science-section3 section-body-content\" >\n    <div class=\"container position-relative\">\n        <div class=\"row\">\n            <div class=\"col-lg-4\">\n                <h3>How <strong>living drugs<\/strong> are made<\/h3>\n                <div class=\"line-anim d-lg-block d-none\"><\/div>\n            <\/div>\n            <div class=\"col-lg-4\">\n                <p>In cell therapies, the patient or donor cells are collected and processed in specialized labs. Here, they are genetically engineered to identify and kill tumor cells.<\/p>            <\/div>\n            <div class=\"col-lg-4\">\n                <div class=\"right-content\">\n                    <p>The cells are grown in number, formulated and re-injected into the patient. The patient now has an army of weaponized T cells with enriched responses that can seek and destroy cancer cells.<\/p>                <\/div>\n                <div class=\"line-anim d-lg-none d-block\"><\/div>\n            <\/div>\n        <\/div>\n        <div class=\"row\">\n            <div class=\"col-lg-12\">\n                <div class=\"ie-imgfix\">\n                    <div class=\"image-name\">Making a living drug (CAR-T)<\/div>\n                    <img decoding=\"async\" src=\"https:\/\/icdlabs.in\/immune-internal\/wp-content\/uploads\/2020\/07\/t-cells-svg.svg\" class=\"d-lg-block d-none\" alt=\"\">\n                    <img decoding=\"async\" src=\"https:\/\/icdlabs.in\/immune-internal\/wp-content\/uploads\/2020\/07\/t-cells-svg-mob.svg\" class=\"d-lg-none d-block\" alt=\"\">\n                    <div class=\"graphic-source\">Source: www.ohcare.com\/service\/car-t-cell-therapy\/<\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n\n<div class=\"lazyblock-science-section-4-13l328 wp-block-lazyblock-science-section-4\"><!-- Include stylesheet -->\n\n<section class=\"science-section4 section-body-content\">\n    <div class=\"container position-relative\">\n        <div class=\"row\">\n            <div class=\"col-lg-4\">\n                <h3>The cell therapy <strong>advantage<\/strong><\/h3>\n            <\/div>\n            <div class=\"col-lg-4\">\n                <div class=\"line-anim science-line-section4\"><\/div>\n                <div class=\"item-cont\">\n                    <div class=\"item-heading\">One shot cure<\/div>\n                    <div class=\"item-text\">The promise of a potential cure or lasting remissions without cancer with a one-time short infusion treatment (typically), quite unlike conventional cancer treatments where successive rounds of treatment are needed.<\/div>\n                <\/div>\n                <div class=\"item-cont\">\n                    <div class=\"item-heading\">Short treatment, quicker recovery<\/div>\n                    <div class=\"item-text\">The absence of aggressive chemotherapy and short treatment time significantly reduces recovery time in patients.<\/div>\n                <\/div>\n                <div class=\"item-cont\">\n                    <div class=\"item-heading\">Long term benefits<\/div>\n                    <div class=\"item-text\">Since these therapies are living drugs with cells that persist, benefits such as protection against relapse can last for many years.<\/div>\n                <\/div>                \n            <\/div>\n            <div class=\"col-lg-4 right-content\">\n                <div class=\"item-cont\">\n                    <div class=\"item-heading\">Acceptance<\/div>\n                    <div class=\"item-text\">For autologous therapies, the cells drawn from the patient\u2019s body when re-injected are accepted readily\u2014there is no host vs graft disease (unlike what is observed in bone marrow transplants). <\/div>\n                <\/div>\n                <div class=\"item-cont\">\n                    <div class=\"item-heading\">Better quality of life<\/div>\n                    <div class=\"item-text\">Without the toxic side-effects typically associated with chemotherapy, or frequent hospital visits for drug infusions, cell therapies provide better quality of life to patients and eases the burden of care for their families.<\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n\n<div class=\"lazyblock-science-section-5-wQK4o wp-block-lazyblock-science-section-5\"><!-- Include stylesheet -->\n\n<div id=\"rnd-roadmap\" class=\"section-id\"><\/div>\n<section class=\"science-section5\">\n    <div class=\"container position-relative\">\n        <div id=\"scienceBlob_container\" style=\"position:absolute; width: 100%; height: 100%;\" class=\"scroll-blob science-blob2\"> \n            <div class=\"inner-blob\"><\/div>\n        <\/div>\n        <!-- <div id=\"scienceBlob_container\" style=\"position:absolute;\" class=\"scroll-blob science-blob2\"> -->\n            <!-- <img decoding=\"async\" src=\"https:\/\/icdlabs.in\/immune-internal\/wp-content\/themes\/immuneel\/assets\/images\/blob.png\" alt=\"\"> -->\n            <!-- <div class=\"inner-blob d-lg-block d-none\"><\/div> -->\n        <!-- <\/div> -->\n        <div class=\"row\">\n            <div class=\"col-lg-4\">\n                <h3>Immuneel\u2019s <strong>R&amp;D roadmap<\/strong><\/h3>\n            <\/div>\n            <div class=\"col-lg-4\">\n                <p><span style=\"font-weight: 400\">As we seek to disrupt cancer care in India, our immediate focus is to treat blood cancers. Immuneel\u2019s first investments in the cell therapy platforms are on autologous CAR-T cell therapies <\/span><span style=\"font-weight: 400\">which have shown promising results in patients<\/span><span style=\"font-weight: 400\">.<\/span><\/p>            <\/div>\n            <div class=\"col-lg-4\">\n                <p>Our first set of development programs are CAR-T cell therapies targeting single and dual receptors for adult lymphomas, adult leukemias and childhood leukemia, in patients who have failed existing therapy.<\/p>\n<p>Our Research &amp; Development center is recognized by DSIR (Department of Scientific and Industrial Research, Government of India).<\/p>            <\/div>\n        <\/div>\n        <div class=\"row\">\n            <div class=\"col-lg-4 offset-lg-4\">\n                            <\/div>\n            <div class=\"col-lg-4\">\n                            <\/div>\n        <\/div>\n        <!-- <div class=\"graphic-container\">\n            <div class=\"row\">\n                <div class=\"col-lg-8 no-padding\">\n                    <div class=\"image-name\"><\/div>\n                    <div class=\"graphic-img-wrapper ie-imgfix\">\n                        <img decoding=\"async\" src=\"\" alt=\"\" class=\"d-md-block d-none\">\n                        <img decoding=\"async\" src=\"\" alt=\"\" class=\"d-md-none d-block\">\n                    <\/div>\n                    <div class=\"source-wrapper\">\n                        <div class=\"graphic-source\"><\/div>\n                        <div class=\"graphic-source scroll-img d-none\">Swipe for more ><\/div>\n                    <\/div>\n                <\/div>\n                <div class=\"col-lg-4\">\n                    <div class=\"section-body-content\">\n                                            <\/div>\n                <\/div>\n            <\/div>\n        <\/div> -->\n    <\/div>\n<\/section><\/div>\n\n<div class=\"lazyblock-science-section-6-24EiSg wp-block-lazyblock-science-section-6\"><!-- Include stylesheet -->\n\n<section class=\"science-section6\" id=\"cart-cell-therapy\">\n    <div class=\"container position-relative\">\n        <div class=\"row\">\n            <div class=\"col-lg-4\">\n                <div class=\"section-body-content\">\n                    <h3><strong>CAR-T cell therapy:<\/strong> The current frontier of cell therapies<\/h3>\n                    <p>CAR stands for <em>Chimeric Antigen Receptor;<\/em> the T refers to T cell, a type of killer cell in the immune system.<\/p>                <\/div>\n            <\/div>\n            <div class=\"col-lg-8\">\n                <!-- <div class=\"row\"> -->\n                    <div class=\"line-anim\"><\/div>\n                    <!-- <div class=\"col-lg-6\">\n                        <p>Normally, T cells have receptors on their surfaces which can detect and attach to any disease cell and kill it. However, in cancer, tumor cells can escape detection by T cells and proliferate.<\/p>\n<p>In autologous CAR-T cell therapy, the patient\u2019s T-cells are extracted, genetically modified and re-injected. These genetically modified cells can be programmed to express new receptors on the cell surface and\/or be activated to recognize markers on the cancerous cell allowing them to bind to the cancer cell and kill it.<\/p>\n<p>These genetically modified cells combine both antigen-binding and T cell activating functions through a single receptor.<\/p>                    <\/div>\n                    <div class=\"col-lg-6 para-padding\">\n                                            <\/div> -->\n                    <div class=\"col-count\">\n                        <p>Normally, T cells have receptors on their surfaces which can detect and attach to any disease cell and kill it. However, in cancer, tumor cells can escape detection by T cells and proliferate.<\/p>\n<p>In autologous CAR-T cell therapy, the patient\u2019s T-cells are extracted, genetically modified and re-injected. These genetically modified cells can be programmed to express new receptors on the cell surface and\/or be activated to recognize markers on the cancerous cell allowing them to bind to the cancer cell and kill it.<\/p>\n<p>These genetically modified cells combine both antigen-binding and T cell activating functions through a single receptor.<\/p>                    <\/div>\n                <!-- <\/div> -->\n                <div class=\"science-section3-anim ie-anim-fix\" id=\"scienceAnim3\"><\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>\n\n<div class=\"lazyblock-science-section-7-Z1LNC90 wp-block-lazyblock-science-section-7\"><!-- Include stylesheet -->\n\n<section class=\"science-section7\">\n    <div class=\"container position-relative\">\n        <!-- <div id=\"scienceblob7_container\" style=\"position:absolute; width: 100%; height: 100%;\" data-size=220 data-color=\"#44BFE6\" class=\"blob-anim-cont science-blob7 scale-anim\"><\/div> -->\n        <div class=\"row\">\n            <div class=\"col-lg-4\">\n                <h3><strong>Collaborating globally<\/strong> to advance our research<\/h3>\n            <\/div>\n            <div class=\"col-lg-8\">\n                <div class=\"col-count\">\n                    <p>Immuneel is committed to continue its development efforts into next generation cellular immunotherapy platforms and technologies aimed at various cancers and other rare diseases.<\/p>\n<p>We are collaborating with our partners globally on targets beyond lymphomas and leukemias, platforms beyond autologous therapies, towards advancing technology in construction design, and building more efficiency in process development, manufacturing and delivery to provide affordable solutions.<\/p>\n<p>Our collaborations will enable our mid to long term pipeline delivery.<\/p>                <\/div>\n            <\/div>\n            <!-- <div class=\"col-lg-4\">\n                <p>Immuneel is committed to continue its development efforts into next generation cellular immunotherapy platforms and technologies aimed at various cancers and other rare diseases.<\/p>\n<p>We are collaborating with our partners globally on targets beyond lymphomas and leukemias, platforms beyond autologous therapies, towards advancing technology in construction design, and building more efficiency in process development, manufacturing and delivery to provide affordable solutions.<\/p>\n<p>Our collaborations will enable our mid to long term pipeline delivery.<\/p>            <\/div>\n            <div class=\"col-lg-4\">\n                            <\/div> -->\n        <\/div>\n        <div class=\"cancers-container\">\n            <div class=\"row\">\n                <div class=\"col-lg-4\">\n                    <div class=\"blood-cancer\">\n                        <div class=\"inner-blob scale-anim blob1\"><\/div>\n                        <div class=\"tumor-wrapper\">\n                            <div class=\"tumor-icon blood-cancer-icon\"><\/div>\n                            <div class=\"tumor-heading\">\n                                Blood cancers to solid tumours                            <\/div>\n                            <div class=\"tumor-text\">\n                                <p>\n                                    Immuneel is currently focused on treatments for leukemias and lymphomas. It aims to develop cell therapies for other diseases like solid tumours as well.                                <\/p>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                    \n                <\/div>\n                <div class=\"col-lg-4\">\n                    <div class=\"allogeneic-cancer\">\n                        <div class=\"inner-blob scale-anim blob2\"><\/div>\n                        <div class=\"tumor-wrapper\">\n                            <div class=\"tumor-icon allogeneic-cancer-icon\"><\/div>\n                            <div class=\"tumor-heading\">\n                                Autologous to allogeneic                            <\/div>\n                            <div class=\"tumor-text\">\n                                <p>\n                                    Current treatments  like CAR-T are autologous\u2014a  personalised treatment, made by weaponizing the patient&#8217;s own immune cells. In the future, the aim is to make  available a non-personalised, off-the-shelf version of cell and gene medicines. Called allogeneic, they will use human immune cells, but not the patient\u2019s own.                                 <\/p>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n                <div class=\"col-lg-4\">\n                    <div class=\"cart-cancer\">\n                        <div class=\"inner-blob scale-anim blob3\"><\/div>\n                        <div class=\"tumor-wrapper\">\n                            <div class=\"tumor-icon cart-cancer-icon\"><\/div>\n                            <div class=\"tumor-heading\">\n                                Beyond CAR-T                            <\/div>\n                            <div class=\"tumor-text\">\n                                <p>\n                                    While CAR-T can revolutionise cancer treatment today, it also opens the door to other cell and gene therapies, which harness the body\u2019s cells to combat disease. Innovation will aim to improve every aspect of the treatment: the cells targeted, the modifications we design and the methods of delivering curative cells.                                <\/p>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-555","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/pages\/555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/comments?post=555"}],"version-history":[{"count":5,"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/pages\/555\/revisions"}],"predecessor-version":[{"id":1664,"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/pages\/555\/revisions\/1664"}],"wp:attachment":[{"href":"https:\/\/icdlabs.in\/immune-internal\/wp-json\/wp\/v2\/media?parent=555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}